![]() Most of amphetamine's effects are believed to be due to its ability to stimulate the release of biogenic amines (norepinephrine and dopamine) from their storage sites in the nerve terminals. Main effects of acute administration are wakefulness, decreased sense of fatigue, elevation of mood, and increased ability to concentrate. Aschner, in Encyclopedia of the Neurological Sciences (Second Edition), 2014 AbstractĪmphetamine has powerful central nervous system (CNS) stimulant actions, in addition to peripheral actions typical of indirect sympathomimetic drugs. Usual daily dosage range: 5–60 mg/24 hr in divided doses. ![]() Incremental doses may be administered with the first dose at awakening and subsequent doses (5 or 10 mg) spaced at 4–6 hr intervals. ≥13 yr and adult: 10 mg QAM increase by 10 mg/24 hr at weekly intervals until desired response. Immediate release tabs (Evekeo and generics PO):Ħ–12 yr: 5 mg QAM increase by 5 mg/24 hr at weekly intervals until desired response. If converting from Adderall XR, see dosage equivalent information in Adzenys XR-ODT product information. ≥6 yr and adolescent: Start at 2.5 or 5 mg/24 hr QAM increase by 2.5–10 mg/24 hr every 4–7 days until desired response up to a maximum doseĪ If converting from Adderall XR, see dosage equivalent information in Adzenys ER product information.Įxtended-release dispersible tabs (see how supplied section, earlier Adzenys XR-ODT PO):Ħ–17 yr: 6.3 mg/24 hr QAM increase by 3.1 or 6.3 mg/24 hr at weekly intervals until desired response. 6–17 yr: Start at 6.25 mg/24 hr QAM increase by 3.125–6.25 mg every 7 days until desired response up to the maximum dose
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